United defender Wes Brown will miss England's Euro 2008 qualifier against Estonia on Saturday with a knee injury.
The versatile defender sat out United's wins over Roma and Wigan after sustaining the knock at Birmingham, but still joined up with Steve McClaren's side, however, with a view to playing at Wembley.
Manchester United midfielder Michael Carrick will be out of action for up to six weeks with a fractured right elbow.
The injury also means the 26-year-old will miss England's crucial upcoming Euro 2008 qualifying games against Estonia and Russia.
He suffered the injury during the latter stages of United's Champions League victory over Roma on Tuesday.
Roy Keane aims to bring Manchester United defenders Jonny Evans and Danny Simpson back to Sunderland in the January transfer window.
Both enjoyed a successful spell last season as Keane guided the Black Cats back to the Premier League.
Keane said: "If I thought there was an opportunity to bring Jonny to Sunderland, we would consider it.
Manchester United defender Gary Neville is poised to make his long-awaited return from injury when he plays for the reserves on Thursday.
Neville has been out since March with calf and ankle problems but he resumed training late last month.
Boss Sir Alex Ferguson said: "We are hoping to use Gary against Liverpool reserves this week. That's the plan.
Ryan Giggs has paid tribute to Gerard Pique, Danny Simpson and Anderson for their contributions in the 4-0 victory over Wigan.
"Pique came in at centre-half and did a good job, and so did Simmo," Giggs told the club's official website.
"They got two assists really, so overall it was a really good performance from them both."
Manchester United's attacking trio of Carlos Tevez, Cristiano Ronaldo and Wayne Rooney put their side top of the table for the first time this season.
United suffered two more injuries in the first half when Nemanja Vidic and John O'Shea had to go off, two substitutions that disrupted the champions' impressive early rhythm.
Sir Alex Ferguson believes Manchester United were a 'little lucky' to beat Roma.
Ferguson praised Tomasz Kuszczak on his Champions League debut, but admitted Roma failed to make the most of their chances.
"He was excellent. He made a couple of good saves and made a good block in the second half," Ferguson said.
Manchester United have been dealt a blow with the news that Owen Hargreaves requires another month on the sidelines.
The England international had been tipped to make his comeback in Tuesday's UEFA Champions League clash with Roma.
However, Hargreaves felt his knee in training on Monday and now United have opted to give him an injection in his knee.
Wayne Rooney confessed that Roma deserved a point for their performance at Old Trafford.
“I think Roma played really well tonight. We knew it was going to be more difficult than last season,” he told Sky Italia television.
“They played well and honestly the fair result was probably a draw, but we held on to the win.”
Wayne Rooney's first goal of the season fired Manchester United to victory against Roma at Old Trafford. Rooney broke the deadlock with a sharp 15-yard finish after he was set up by Nani to leave United three points clear at the top of Group F.