Ryan Giggs, Owen Hargreaves, Rio Ferdinand and Wes Brown are all in contention for Sunday's Barclays Premier League clash with Blackburn Rovers at Old Trafford after being rested for the midweek win over Dynamo Kyiv.
The quartet watched from the stands as the Reds thrashed the Ukrainians 4-0, booking their place in the Champions League knockout stages.
Manchester United boss Sir Alex Ferguson has hinted he could rotate his squad more after having a strong bench at his disposal against Arsenal.
With the likes of Michael Carrick and Louis Saha available after injury, The Red Devils manager had five internationals at his disposal for the 2-2 draw at Emirates Stadium.
William Gallas equalised in injury-time to salvage a draw and keep Arsenal on top of the Premier League after an absorbing clash with Manchester United.
The opening 45 minutes proved an anti-climax until Gallas diverted Rooney's tame shot in on the stroke of half-time.
Wayne Rooney scored one goal and superbly set up another as Manchester United overwhelmed Middlesbrough to move to the top of the Premier League.
Two goals from Cristiano Ronaldo helped a dominant Manchester United to a comfortable victory at Dynamo Kiev.
Kiev's defence was poor. Actually to be blunt, they were awful for much of the match. They looked disjointed against a United side whose attacking wave of Carlos Tevez, Rooney, Ronaldo and Giggs were a cut above sublime.
UNITED recovered from an early scare to ease to victory over nine-man Aston villa. The home side had taken the lead through Gabriel Agbonlahor, but United big guns Wayne Rooney (two) Rio Ferdinand and Ryan Giggs ensured the Reds jumped back up to second in the Premier League table.
Michael Carrick says United's solid backline has provided the perfect platform on which to build this season's title challenge.
Rio and co. currently hold the best defensive record in the country, with just two goals conceded, and Carrick believes it will stand the Reds in good stead over the course of the campaign.
United defender Wes Brown will miss England's Euro 2008 qualifier against Estonia on Saturday with a knee injury.
The versatile defender sat out United's wins over Roma and Wigan after sustaining the knock at Birmingham, but still joined up with Steve McClaren's side, however, with a view to playing at Wembley.
Sir Alex Ferguson is sweating on the fitness of Owen Hargreaves, Nemanja Vidic and Wes Brown as the Old Trafford boss looks to make it two wins from two in Europe this season.
Manchester United defenders Wes Brown and Nemanja Vidic were missing from training today ahead of tomorrow night's Champions League clash with Roma.
The pair picked up knocks during Saturday's Premier League win at Birmingham and while there was no guidance from United as to whether their participation against the Italians was in doubt, it would be a major surprise if either missed out.